Exploring genetic manipulation of human Prevotella species for health insights
Official title: New advances to break the genetic tractability barrier of human Prevotella species
Funded at Oregon Health & Science University · NIH-11138198 · Data updated 2026-11-12
This study is looking at certain bacteria in your mouth that can affect your health, and it's trying to find new ways to change their genes to better understand how they might be linked to problems like infections and cancers, which could help improve treatments for these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | June 10, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $234,000 |
| NIH project number | 1R21DE034151-01A1 |
| Project ID | NIH-11138198 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with oral health issues or conditions linked to Prevotella species, such as abscesses or certain cancers.
✕Less likely to help
Patients without any oral health issues or those not affected by conditions related to Prevotella species may not benefit from this research.
What this research studies
This research investigates the genetic characteristics of Prevotella species, which are important bacteria found in the mouth and linked to various health conditions. The team aims to develop new methods to manipulate the genetics of these bacteria, which could enhance our understanding of their role in diseases like abscesses and cancers. By studying clinical isolates from patients, the researchers hope to uncover how these bacteria interact with the human body and contribute to health and disease. This work could lead to breakthroughs in treating conditions associated with these bacteria.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for infections and cancers associated with Prevotella species.
How similar studies have gone: Previous research has shown promise in manipulating other bacterial species genetically, suggesting potential for success in this novel approach with Prevotella.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Merritt, Justin — Oregon Health & Science University
- Study coordinator: Merritt, Justin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.