Exploring genetic factors in psychiatric disorders using big data
A big data approach to explore epigenetic heterogeneity and interpret noncoding variants for psychiatric disorders
['FUNDING_CAREER'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10640918
This study is looking at how certain genes that don’t make proteins might affect mental health conditions, using advanced technology to better understand the brain, and it’s aimed at finding new ways to help people with psychiatric disorders.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-10640918 on ClinicalTrials.gov |
What this research studies
This research investigates the complex genetic factors that contribute to psychiatric disorders by analyzing noncoding genomic elements that do not directly produce proteins. It employs advanced sequencing technologies and machine learning methods to integrate large-scale genomic data, focusing on the human prefrontal cortex. The goal is to identify key genetic variants and regulatory mechanisms that may lead to new therapeutic targets for mental health conditions. By dissecting the regulatory landscape and constructing gene networks, the research aims to provide deeper insights into the molecular underpinnings of these disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with psychiatric disorders or those with a family history of such conditions.
Not a fit: Patients with purely environmental causes of mental health issues, without any genetic predisposition, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets and improved treatments for psychiatric disorders.
How similar studies have performed: Other research has shown promise in using big data and genomic analysis to uncover genetic factors in psychiatric disorders, indicating a potential for success in this approach.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, JING — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: ZHANG, JING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Mental disorders, Mental health disorders, Psychiatric Disease, Psychiatric Disorder, psychological disorder