Exploring a new molecule for anesthesia
Official title: Discovery and Development of a Benzoquinone Molecule as a Novel Anesthetic
Funded at Columbia University Health Sciences · NIH-10910165 · Data updated 2026-11-12
This study is looking at a new type of anesthetic that could help people go to sleep safely during surgery while also reducing memory loss and side effects, making the whole experience better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $463,770 |
| NIH project number | 5R01GM148716-02 |
| Project ID | NIH-10910165 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals undergoing surgical procedures who require anesthesia and may be at risk for adverse effects from current anesthetic agents.
✕Less likely to help
Patients who are not undergoing surgery or do not require anesthesia will likely not benefit from this research.
What this research studies
This research investigates a novel anesthetic molecule, specifically a synthetic CoQ analog from the 1,4-benzoquinone class, to understand its effects on inducing unconsciousness and preventing memory loss during anesthesia. The study aims to characterize how this molecule interacts with mitochondrial function, which is crucial for its anesthetic properties. By examining the mechanisms of action, the research seeks to develop safer anesthetic options that minimize adverse effects commonly associated with current sedative-hypnotics. Patients may benefit from improved anesthesia experiences with fewer side effects if successful.
Why it matters
Potential benefit: If successful, this research could lead to the development of a safer anesthetic that reduces adverse effects and improves patient outcomes during surgical procedures.
How similar studies have gone: While the approach of using 1,4-benzoquinones as anesthetics is novel, previous studies have shown promise in understanding anesthetic mechanisms, indicating potential for success.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Levy, Richard J — Columbia University Health Sciences
- Study coordinator: Levy, Richard J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.