Exploring a new factor that affects muscle performance and metabolism
Official title: Identifying a novel player in skeletal muscle performance and metabolism
Funded at Ohio University Athens · NIH-11057608 · Data updated 2026-11-12
This study is looking at a protein called FSP27 to see how it affects muscle strength and insulin use, which could help us find better ways to improve muscle function and manage conditions like diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio University Athens NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | April 1, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $589,326 |
| NIH project number | 5R01DK138635-02 |
| Project ID | NIH-11057608 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing metabolic disorders, such as adult-onset diabetes, who may benefit from improved muscle function.
✕Less likely to help
Patients with conditions unrelated to muscle performance or metabolic regulation may not receive any benefit from this research.
What this research studies
This research investigates the role of a specific protein, Fat Specific Protein 27 (FSP27), in regulating muscle function and insulin signaling. By studying both human muscle samples and a specially designed mouse model, the researchers aim to uncover how FSP27 influences muscle strength, endurance, and metabolic health. The approach includes analyzing muscle performance metrics and understanding the molecular pathways involved in fat handling within muscle tissue. This could lead to insights into how to improve muscle function and manage metabolic diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing muscle performance and improving insulin sensitivity in patients, potentially benefiting those with metabolic diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of muscle proteins in metabolic health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ohio University Athens
Athens, United States Active
Researchers
- Principal investigator: Puri, Vishwajeet — Ohio University Athens
- Study coordinator: Puri, Vishwajeet
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.