Examining mitochondrial function in people with schizophrenia
Official title: In vivo assessment of the mitochondrial complex I in subjects with schizophrenia
Funded at New York University School of Medicine · NIH-11056397 · Data updated 2026-11-12
This study is looking at how the energy production in your brain might affect thinking skills if you have schizophrenia, and it will involve some brain scans and tests to help us understand this better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | November 8, 2024 |
| Project end | October 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $254,250 |
| NIH project number | 1R21MH136644-01A1 |
| Project ID | NIH-11056397 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with schizophrenia who experience cognitive impairments.
✕Less likely to help
Patients without a diagnosis of schizophrenia or those with cognitive impairments due to other conditions may not benefit from this research.
What this research studies
This research investigates how mitochondrial function affects cognitive abilities in individuals with schizophrenia. It focuses on the role of energy production in the brain, particularly how disruptions in mitochondrial function may lead to cognitive deficits. By assessing brain activity and energy metabolism, the study aims to understand the underlying mechanisms that contribute to cognitive impairments in schizophrenia. Participants may undergo brain imaging and other assessments to evaluate their cognitive function and mitochondrial health.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments aimed at improving cognitive function in patients with schizophrenia.
How similar studies have gone: Other research has indicated that mitochondrial dysfunction may play a significant role in cognitive deficits, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Frankle, William G — New York University School of Medicine
- Study coordinator: Frankle, William G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.