Evaluating personalized treatments for childhood Sjögren's disease
Planning a childhood sJOgren disease Use of Randomized N-of-1 Evaluation of therapY JOURNEY
This study is looking at how to create better, personalized treatments for kids with Sjögren's disease by testing different therapies to see what works best for each child, so they can feel more comfortable and improve their quality of life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10880455 on NIH RePORTER |
What this research studies
This research focuses on childhood Sjögren's disease, a rare autoimmune condition that causes inflammation in the salivary and tear glands, leading to dryness and discomfort. The study aims to develop personalized treatment strategies using N-of-1 trials, which assess how individual patients respond to specific therapies. By creating patient- and parent-driven outcome measures, the research seeks to better understand the effectiveness of treatments and their impact on quality of life. This approach is designed to fill the gap in pediatric-specific clinical trials for this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with childhood Sjögren's disease who experience symptoms related to glandular inflammation.
Not a fit: Patients with Sjögren's disease who are adults or those without a confirmed diagnosis of the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored treatment options for children suffering from Sjögren's disease.
How similar studies have performed: While N-of-1 trials are a novel approach in this specific context, similar personalized treatment strategies have shown promise in other areas of clinical research.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Singer, Nora — Case Western Reserve University
- Study coordinator: Singer, Nora
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.