Evaluating personalized treatments for childhood Sjögren's disease
Official title: Planning a childhood sJOgren disease Use of Randomized N-of-1 Evaluation of therapY JOURNEY
Funded at Case Western Reserve University · NIH-10880455 · Data updated 2026-11-12
This study is looking at how to create better, personalized treatments for kids with Sjögren's disease by testing different therapies to see what works best for each child, so they can feel more comfortable and improve their quality of life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $297,940 |
| NIH project number | 1R34AR084192-01 |
| Project ID | NIH-10880455 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with childhood Sjögren's disease who experience symptoms related to glandular inflammation.
✕Less likely to help
Patients with Sjögren's disease who are adults or those without a confirmed diagnosis of the condition may not benefit from this research.
What this research studies
This research focuses on childhood Sjögren's disease, a rare autoimmune condition that causes inflammation in the salivary and tear glands, leading to dryness and discomfort. The study aims to develop personalized treatment strategies using N-of-1 trials, which assess how individual patients respond to specific therapies. By creating patient- and parent-driven outcome measures, the research seeks to better understand the effectiveness of treatments and their impact on quality of life. This approach is designed to fill the gap in pediatric-specific clinical trials for this condition.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored treatment options for children suffering from Sjögren's disease.
How similar studies have gone: While N-of-1 trials are a novel approach in this specific context, similar personalized treatment strategies have shown promise in other areas of clinical research.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Singer, Nora — Case Western Reserve University
- Study coordinator: Singer, Nora
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.