Epigenetic control of heart energy by noncoding RNAs in ketosis and fasting
Official title: Epigenetic Regulation of Cardiac Mitochondrial Function by Long Noncoding RNA: Investigating the Impact of Ketosis and Intermittent Fasting in Heart Failure
Funded at Nova Southeastern University · NIH-11401726 · Data updated 2026-11-12
A study in heart failure models to understand how long noncoding RNAs affect heart cell energy when people follow ketosis or intermittent fasting.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nova Southeastern University NIH-funded |
| Lab location | 1 site (Fort Lauderdale-Davie, UNITED STATES) |
| Project start | September 1, 2025 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $156,000 |
| NIH project number | 5R16GM159784-02 |
| Project ID | NIH-11401726 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with heart failure or at risk for it, who could participate in future translation studies or trials related to metabolic therapies.
✕Less likely to help
People with non-cardiac conditions or those unable to participate in metabolic interventions may not benefit.
What this research studies
Researchers will study how specific long noncoding RNAs influence mitochondrial energy production in heart cells under ketogenic conditions, using mouse and human cell models. They will look at how ketosis changes RNA and protein players involved in mitochondrial protection and energy generation. The project combines animal studies and human cell experiments to map links between diet, RNA regulation, and heart cell health. Findings could point to new ways to support heart function in people with heart failure.
Why it matters
Potential benefit: If successful, this work could guide dietary or molecular strategies to improve heart energy and function in heart failure.
How similar studies have gone: Previous work suggests similar RNA pathways influence mitochondrial function and may respond to ketosis, but human relevance is still being explored.
Where this research is happening
-
Nova Southeastern University
Fort Lauderdale-Davie, United States Active
Researchers
- Principal investigator: Gurusamy, Narasimman — Nova Southeastern University
- Study coordinator: Gurusamy, Narasimman
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.