NIH-funded research R01 grant

Enhanced problem-solving therapy and HIV engagement support to improve mental health and HIV outcomes for women with HIV in Malawi

Official title: Enhanced problem-solving therapy and HIV engagement support to improve perinatal mental health and HIV outcomes in Malawi: A randomized controlled trial

Funded at Univ of North Carolina Chapel Hill · NIH-11286623 · Data updated 2026-11-12

This trial tests a counseling-based program designed to support perinatal mental health and keep women with HIV engaged in HIV care after birth in Malawi.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniv of North Carolina Chapel Hill
NIH-funded
Lab location1 site (Chapel Hill, United States)
Project startJuly 22, 2024
Project endFebruary 28, 2029
Funding year2026
Award (this year)$680,129
NIH project number5R01MH134660-03
Project IDNIH-11286623 on NIH RePORTER

Who could benefit from this research

Could help

Women living with HIV who are pregnant or in the postpartum period and are at risk for perinatal depression.

Less likely to help

Individuals without HIV, without perinatal depression symptoms, or not in the perinatal period may not benefit from this specific intervention.

What this research studies

If you are a woman living with HIV and are pregnant or have recently given birth, this study will offer a counseling approach to help with perinatal depression and to strengthen staying in HIV care. The researchers built on earlier work that showed the approach is acceptable and feasible, and they will rigorously test whether it improves mood and keeps HIV treatment on track after delivery. The study uses a randomized design to compare the counseling program with standard care, with careful attention to how it could be implemented in real-world clinics. Outcomes include mental health symptoms and engagement in HIV care, with a focus on rapid translation into practice if successful.

Why it matters

Potential benefit: If successful, participants may experience better mood during the perinatal period and more consistent HIV care engagement after birth.

How similar studies have gone: A pilot randomized trial previously showed acceptability, feasibility, and potential efficacy for improving perinatal depression and HIV care engagement.

Where this research is happening

  • Univ of North Carolina Chapel Hill
    Chapel Hill, United States
    Active

Researchers

  • Principal investigator: Pence, Brian W — Univ of North Carolina Chapel Hill
  • Study coordinator: Pence, Brian W

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.