Engineering synthetic gene circuits to improve their effectiveness in fighting infections and cancers
Multi-Scale Engineering of Heterogeneity in the Host-Aware Synthetic Gene Circuits
This study is all about making special DNA circuits that help control how cells behave, with the goal of making them more dependable for treating things like bacterial infections and cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-10908275 on NIH RePORTER |
What this research studies
This research focuses on improving synthetic gene circuits, which are engineered DNA sequences that can control cell behavior. By understanding how these circuits interact with their host cells, the researchers aim to reduce variability in their performance, making them more reliable for medical applications. The project involves both experimental and computational methods to quantify and control these interactions, ultimately leading to better-designed gene circuits that can be used in therapies for bacterial infections and cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with bacterial infections or cancers who may benefit from advanced gene therapy approaches.
Not a fit: Patients with conditions unrelated to bacterial infections or cancers may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for infections and cancers by optimizing how synthetic gene circuits function within the body.
How similar studies have performed: Previous research has shown promise in optimizing synthetic gene circuits, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Tian, Xiaojun — Arizona State University-Tempe Campus
- Study coordinator: Tian, Xiaojun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.