Emerin self-assembly at the nuclear envelope and Emery-Dreifuss muscular dystrophy
Official title: Mechanisms and regulation of emerin self-assembly at the nuclear envelope: Implication for Emery-Dreifuss Muscular Dystrophy
Funded at University of Southern California · NIH-11380607 · Data updated 2026-11-12
Aims to understand how emerin proteins organize themselves at the nuclear envelope to protect muscle cell nuclei, with the goal of helping people with Emery-Dreifuss muscular dystrophy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | August 10, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $335,113 |
| NIH project number | 5R01AR085676-02 |
| Project ID | NIH-11380607 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with Emery-Dreifuss muscular dystrophy or related nuclear envelope disorders, who may benefit from improved understanding of disease mechanisms.
✕Less likely to help
People without EDMD or related nuclear envelope conditions may not directly benefit from this basic mechanistic research.
What this research studies
This project studies how emerin, a key protein of the inner nuclear envelope, forms self-assembled structures that influence nuclear shape and response to mechanical stress. By combining proteomics, advanced cell imaging, and single-molecule studies, the team will map how emerin self-assembly is regulated in muscle and non-muscle cells. The findings could reveal targets to prevent nucleus damage in EDMD and guide future therapies.
Why it matters
Potential benefit: In the long run, insights into emerin assembly could lead to strategies that preserve muscle cell integrity in EDMD patients.
How similar studies have gone: Previous work shows that emerin assembly is linked to nuclear mechanics, supporting a promising path for this study.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Pinaud, Fabien — University of Southern California
- Study coordinator: Pinaud, Fabien
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.