Elucidating How Necroptosis Works in Disease
Official title: Elucidating the Molecular Basis of Necroptosis
Funded at University of California Berkeley · NIH-11430555 · Data updated 2026-11-12
Aims to uncover the detailed molecular steps of necroptosis to better understand and eventually treat diseases linked to skin inflammation, gut inflammation, and brain disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | August 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $329,491 |
| NIH project number | 1R35GM166219-01 |
| Project ID | NIH-11430555 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with inflammatory or neurodegenerative diseases where necroptosis is involved may benefit from future therapies arising from this research.
✕Less likely to help
Healthy individuals or patients without necroptosis-related pathology may not directly benefit.
What this research studies
This project looks at how a specific form of cell death called necroptosis happens at the molecular level, focusing on the ZBP1–RIPK3–MLKL pathway. Researchers will map how the ZBP1 sensor recognizes ligands, how RIPK3 passes signals, and how MLKL forms pores to cause cell death and inflammation. The work uses advanced molecular and cellular techniques to compare human and model organism versions of these proteins to see what is conserved or different. By detailing these steps, scientists hope to identify new targets to prevent harmful cell death in diseases like dermatitis and neurodegenerative conditions.
Why it matters
Potential benefit: Understanding necroptosis could lead to new therapies that reduce inflammation and tissue damage in several diseases.
How similar studies have gone: Previous work has clarified other cell death pathways, and this project advances knowledge specifically on necroptosis with novel mechanistic insights.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Xia, Shiyu — University of California Berkeley
- Study coordinator: Xia, Shiyu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.