Effects of fasting and exercise on fatigue in women with advanced breast cancer
Official title: Randomized Phase II Trial of Prolonged Overnight Fasting and/or Exercise on Fatigue and Other Patient Reported Outcomes in Women with Hormone Receptor Positive Advanced Breast Cancer (FastER)
Funded at University of Miami School of Medicine · NIH-10932148 · Data updated 2026-11-12
This study is looking at how skipping breakfast and exercising might help women with advanced breast cancer feel less tired and improve their quality of life, especially for those from diverse backgrounds facing unique challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $732,901 |
| NIH project number | 5R01CA281861-02 |
| Project ID | NIH-10932148 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with hormone receptor positive advanced breast cancer who are experiencing fatigue as a side effect of their treatment.
✕Less likely to help
Patients with early-stage breast cancer or those not experiencing significant fatigue may not benefit from this research.
What this research studies
This research investigates how prolonged overnight fasting and exercise can help reduce fatigue and improve quality of life for women with hormone receptor positive advanced breast cancer. Participants will be randomly assigned to different groups to assess the impact of these lifestyle interventions on their symptoms and overall well-being. The study aims to gather data from a diverse group of women, particularly focusing on those from underrepresented backgrounds who may experience unique challenges related to their treatment. By exploring these strategies, the research seeks to provide insights into effective ways to manage treatment-related fatigue.
Why it matters
Potential benefit: If successful, this research could lead to improved management of fatigue and enhanced quality of life for women undergoing treatment for advanced breast cancer.
How similar studies have gone: Previous research has shown that lifestyle interventions like diet and exercise can improve fatigue in early-stage breast cancer, but this specific approach for advanced cases is still being explored.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Crane, Tracy E — University of Miami School of Medicine
- Study coordinator: Crane, Tracy E
Related research
Other NIH-funded projects on the same topics.
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Longer overnight fasting and exercise to reduce fatigue in women with hormone receptor–positive advanced breast cancer
This project will see if longer overnight fasting and regular exercise help women with hormone receptor–positive advanced breast cancer feel less fatigued and improve their quality of life.
-
Radiomic markers from 3D mammography to predict breast cancer risk across diverse women
A Mayo Clinic team is testing advanced computer-derived features from 3D mammograms to improve predicting who will develop breast cancer, including diverse groups of women.
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Improving how the immune system fights advanced breast cancer by relieving tumor pressure
A breast cancer treatment study tests whether a common blood pressure drug (losartan) can help immune cells get into tumors and work better with immunotherapy.
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Using a blood test that looks for tumor DNA to monitor early and locally advanced breast cancer
This project uses a sensitive blood test that looks for tiny bits of tumor DNA to track treatment response in people with early or locally advanced breast cancer.
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Personalizing estrogen therapy for ER-positive breast cancer
This project finds how the hormone estrogen can kill certain ER-positive breast cancers and how to tell which patients will benefit.
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Energize-MBC: a web-based fatigue program for women with metastatic breast cancer
This project will adapt a cognitive behavioral therapy program delivered online to help women with metastatic breast cancer who have tiring side effects from CDK4/6 inhibitor treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.