Editing genes to treat cardiovascular disease
Official title: Base editing of ASGR1 for cardiovascular disease
Funded at Indiana University Indianapolis · NIH-10829341 · Data updated 2026-11-12
This study is exploring a new way to fix genetic issues that lead to heart problems, like atherosclerosis, by using a special technique to change specific genes, which could help improve heart health for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | April 17, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $237,750 |
| NIH project number | 5R21HL163720-02 |
| Project ID | NIH-10829341 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic predispositions to cardiovascular diseases, particularly those with high cholesterol or triglyceride levels.
✕Less likely to help
Patients with cardiovascular diseases not linked to genetic factors or those who do not have specific genetic mutations targeted by this research may not benefit.
What this research studies
This research focuses on using advanced gene editing techniques to correct genetic mutations that contribute to cardiovascular diseases, particularly atherosclerosis. By employing a method called base editing, the researchers aim to precisely modify genes involved in lipid metabolism, which is crucial for reducing the risk of heart disease. The study will utilize adeno-associated viruses to deliver these gene-editing tools directly to the heart, potentially leading to significant improvements in heart health. Patients may benefit from new therapeutic options that target the underlying genetic causes of their cardiovascular conditions.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly reduce the risk of heart disease and improve overall cardiovascular health.
How similar studies have gone: Other research has shown promising results using gene editing technologies for similar conditions, indicating a potential for success in this novel approach.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Han, Renzhi — Indiana University Indianapolis
- Study coordinator: Han, Renzhi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.