Ebola Virus Disease Treatment: adjunctive GI therapies to improve survival
Official title: Ebola Virus Disease Treatment
Funded at Rhode Island Hospital · NIH-11394310 · Data updated 2026-11-12
A project using data from past Ebola outbreaks to see if common GI medicines like omeprazole, metronidazole, and albendazole could help reduce death rates.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | August 16, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $330,248 |
| NIH project number | 5P20GM156688-02 |
| Project ID | NIH-11394310 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have or had Ebola virus disease and where GI symptoms were present or treated with omeprazole, metronidazole, or albendazole in historical outbreak data.
✕Less likely to help
If no association is found between GI therapies and outcomes, patients may not benefit from these specific adjunctive treatments.
What this research studies
This project looks at real-world data from historical Ebola outbreaks to understand whether familiar gastrointestinal medications might improve outcomes for patients with Ebola. Researchers will apply new statistical methods, such as propensity score matching, to compare outcomes with and without these adjunctive treatments. The focus is on how gut health and related treatments could influence survival and other clinical outcomes in Ebola patients. The work aims to uncover actionable insights that could inform care during future outbreaks. Results could help clinicians make evidence-based decisions about supportive GI therapies for Ebola patients.
Why it matters
Potential benefit: If successful, the findings could guide existing care to reduce death rates in Ebola outbreaks by using adjunctive GI therapies.
How similar studies have gone: Previous outbreaks have generated large datasets; applying advanced analysis to this data is a promising but exploratory step.
Where this research is happening
-
Rhode Island Hospital
Providence, United States Active
Researchers
- Principal investigator: Genisca, Alicia — Rhode Island Hospital
- Study coordinator: Genisca, Alicia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.