Dynamic Regulation of Erythropoietin Gene Expression in Mammals
Official title: Dynamic Regulation of Erythropoietin Gene Expression in Mammals.
Funded at James J Peters VA Medical Center · NIH-11264855 · Data updated 2026-11-12
Aims to understand how the body normally controls erythropoietin (Epo) production to improve anemia treatment and safety.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James J Peters VA Medical Center NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | April 1, 2009 |
| Project end | December 31, 2028 |
| Funding year | 2026 |
| NIH project number | 5I01BX000446-15 |
| Project ID | NIH-11264855 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with anemia, especially those with heart failure or other illnesses who might benefit from safer Epo-based therapies.
✕Less likely to help
Healthy individuals or patients with anemia who are well-managed on current therapies may experience limited direct benefit.
What this research studies
This project explores how the body’s oxygen-sensing system, especially HIF-2, controls Epo production in kidneys and liver. It discusses how current Epo therapies can cause side effects like blood clots and high blood pressure when given as non-physiological boluses. By studying the natural regulatory mechanisms and how drugs that affect HIF signaling work, the research seeks to pave the way for safer anemia treatments that more closely mimic the body’s own regulation. The work may involve molecular and cellular studies to understand PTMs and PHD enzymes that influence Epo levels. Findings could inform future therapies that reduce risks while maintaining effective red blood cell production.
Why it matters
Potential benefit: Could lead to safer, more physiologic treatments for anemia that minimize risk of thrombosis and other side effects.
How similar studies have gone: Previous research has shown that targeting the HIF pathway can alter Epo production and anemia management, with ongoing exploration of safer PHDi strategies.
Where this research is happening
-
James J Peters VA Medical Center
Bronx, United States Active
Researchers
- Principal investigator: Garcia, Joseph Anthony — James J Peters VA Medical Center
- Study coordinator: Garcia, Joseph Anthony
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.