Dynamic control of mitochondrial function by CLPX protein unfoldase
Official title: Dynamic control of mitochondrial function by the protein unfoldase CLPX
Funded at Brandeis University · NIH-11359597 · Data updated 2026-11-12
A scientist at Brandeis University is studying how the CLPX protein helps mitochondria manage their proteins, with the goal of understanding how this affects blood cancers and other diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brandeis University NIH-funded |
| Lab location | 1 site (Waltham, United States) |
| Project start | August 10, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $317,458 |
| NIH project number | 5R01GM151332-04 |
| Project ID | NIH-11359597 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with mitochondrial disorders or cancers where CLPX/CLPP pathways are implicated, or individuals contributing biological samples for related studies.
✕Less likely to help
Patients without mitochondrial or CLPX/CLPP-related disease may not directly benefit from this basic science project.
What this research studies
This project looks at how the CLPX unfoldase controls which mitochondrial proteins are turned on or off, and how it interacts with its partner CLPP to regulate important processes like heme production. Researchers will map substrate selection and how CLPX decides when to unfold targets, using proteomics and cellular models. Insights could reveal new angles on how mitochondrial dysfunction contributes to blood diseases and cancer, potentially guiding future therapies. The work connects basic molecular biology to higher-level cell behavior, with implications for diseases involving mitochondria.
Why it matters
Potential benefit: Better understanding of mitochondrial regulation may inform future treatments for diseases linked to CLPX/CLPP dysfunction.
How similar studies have gone: Previous research has linked CLPX/CLPP dysfunction to disease and cancer progression, supporting further investigation in this pathway.
Where this research is happening
-
Brandeis University
Waltham, United States Active
Researchers
- Principal investigator: Kardon, Julia R. — Brandeis University
- Study coordinator: Kardon, Julia R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.