Roles of Recycling Endosomes in Neuronal EV Cargo Traffic
Official title: Roles of Recycling Endosomes in Neuronal Extracellular Vesicle Cargo Traffic
Funded at Brandeis University · NIH-11617684 · Data updated 2026-11-12
A scientist at Brandeis University is studying how brain cells control the tiny vesicles they release, which may affect memory loss in Alzheimer’s disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brandeis University NIH-funded |
| Lab location | 1 site (Waltham, United States) |
| Project start | December 1, 2017 |
| Project end | November 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $79,452 |
| NIH project number | 3R01NS103967-09S1 |
| Project ID | NIH-11617684 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with Alzheimer’s disease or related cognitive syndromes for future translational work and those contributing biological samples for related studies.
✕Less likely to help
People without neurodegenerative conditions or those not involved in EV/synaptic research may not directly benefit from this specific basic science project.
What this research studies
This project looks at how recycling endosomes inside neurons influence what gets packed into extracellular vesicles and released at synapses, using live fruit-fly models to map the process. The researchers will combine genetics, biochemistry, and high-resolution imaging to track EV cargo flow in vivo. The aim is to uncover how trafficking routes affect signaling and potentially contribute to Alzheimer-related changes in neural communication. Insights from this work could point to new ways to intervene in neuron communication at the synapse. The findings may help identify targets to modulate EV traffic and synaptic function in neurodegenerative conditions.
Why it matters
Potential benefit: If successful, the work could reveal new targets to preserve synaptic communication in Alzheimer’s disease and guide future therapies.
How similar studies have gone: Previous studies have shown that trafficking pathways influence EV cargo in neurons, supporting potential relevance to human disease.
Where this research is happening
-
Brandeis University
Waltham, United States Active
Researchers
- Principal investigator: Rodal, Avital Adah — Brandeis University
- Study coordinator: Rodal, Avital Adah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.