Disparities, aging markers, and accelerated heart aging in young cancer survivors
Official title: Role of disparities and aging biomarkers in accelerated cardiac aging among adolescent and young adult cancer survivors
Funded at University of Tx Md Anderson Can Ctr · NIH-11373537 · Data updated 2026-11-12
Researchers will study why some adolescent and young adult cancer survivors develop faster aging of the heart and how this differs across groups, using biomarkers and follow-up data to identify who is at greatest risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 10, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,853,125 |
| NIH project number | 4R01CA285599-03 |
| Project ID | NIH-11373537 on NIH RePORTER |
Who could benefit from this research
✓Could help
ADULT-ALIGNED AYA cancer survivors (ages 15-39 at diagnosis) who received cardiotoxic therapy and are available for long-term follow-up.
✕Less likely to help
Individuals without a history of cardiotoxic cancer treatment or those not in the survivor population may not experience direct benefits.
What this research studies
This project follows adolescents and young adults who have survived cancer to understand why their hearts may age faster after certain treatments. It will look at aging biomarkers and how they relate to heart function over time in up to 1,200 survivors. The study combines clinical assessments, biomarker analyses, and subgroup comparisons to see who is most at risk and why. The goal is to identify early indicators so clinicians can tailor monitoring and interventions for AYAs affected by cardiotoxic cancer therapies.
Why it matters
Potential benefit: If successful, findings could lead to earlier detection and personalized care to prevent heart problems in AYA cancer survivors.
How similar studies have gone: Previous work suggests aging-related cardiovascular changes in cancer survivors; this study extends to a larger, diverse AYA population with biomarker integration.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Hildebrandt, Michelle a T — University of Tx Md Anderson Can Ctr
- Study coordinator: Hildebrandt, Michelle a T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.