Differences in glioma outcomes between men and women
Sex-based Differences in Glioma
This study is looking at how being male or female might change the way glioblastoma, a serious brain tumor, affects people, especially why women often live longer than men after diagnosis, with the goal of finding better treatments for everyone.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10881796 on NIH RePORTER |
What this research studies
This research investigates how sex-based differences affect the incidence and outcomes of glioblastoma, the most common malignant brain tumor. It aims to understand the molecular and cellular mechanisms that contribute to these differences, particularly why women tend to have better survival rates than men. By analyzing genomic data and conducting experiments, the research seeks to identify specific molecular alterations linked to sex, which could lead to more tailored treatment approaches. The project involves a collaborative team of experts who will integrate their findings to improve clinical trial designs and therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with glioblastoma, particularly those who are male or female, as the study focuses on sex-based differences in the disease.
Not a fit: Patients with glioblastoma who do not identify as male or female may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, sex-specific treatments for glioblastoma, improving survival rates and outcomes for patients.
How similar studies have performed: Previous research has indicated that sex-based differences in cancer outcomes exist, suggesting that this approach could yield significant insights and improvements in treatment.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Lathia, Justin D. — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Lathia, Justin D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.