Dietary fiber, gut bacteria, and gut transplant health
Official title: Dietary fiber, mucin-degrading Bacteroides, and intestinal GVHD
Funded at Beckman Research Institute/city of Hope · NIH-11417318 · Data updated 2026-11-12
A nutrition-focused NIH grant looks at how fiber and gut bacteria affect the health of people who have received bone marrow or stem cell transplants.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | September 21, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $472,873 |
| NIH project number | 5P01HL170046-03 |
| Project ID | NIH-11417318 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients undergoing allogeneic bone marrow or stem cell transplantation who are able to participate in dietary and microbiome-related assessments.
✕Less likely to help
Patients not receiving a transplant or those unable to follow dietary study requirements may not benefit.
What this research studies
This project explores how what we eat, especially dietary fiber, shapes the gut microbiome after an allogeneic bone marrow transplant. It aims to understand how specific gut bacteria, like Bacteroides thetaiotaomicron, interact with dietary components to influence the gut lining and immune responses. By studying these interactions in human-relevant models, researchers hope to identify dietary strategies that could reduce complications and support recovery after transplant. The work combines microbiome analysis with molecular studies to link diet, bacteria, and host health in the transplant setting.
Why it matters
Potential benefit: If successful, findings could guide dietary recommendations to support gut health and reduce transplant-related complications.
How similar studies have gone: Previous research has shown that diet and microbiome interactions influence gut health, with growing evidence in transplant settings; this study builds on those insights with a focused bacterial player and dietary fiber.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Martens, Eric C — Beckman Research Institute/city of Hope
- Study coordinator: Martens, Eric C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.