Developing tools to diagnose diseases using immune system data
An Integrated Multilevel Modeling Framework for Repertoire-Based Diagnostics
['FUNDING_R01'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-10829853
This study is looking at the special patterns in your immune system's antibodies and T-cell receptors to help create better and more personalized ways to diagnose infections, autoimmune diseases, and cancers, so you can get the most accurate care possible.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10829853 on ClinicalTrials.gov |
What this research studies
This research focuses on analyzing the unique sequences of antibodies and T-cell receptors in individuals to create a detailed health profile. By employing advanced computational models, the goal is to identify patterns that can help diagnose various conditions, including infections, autoimmune diseases, and cancers. The researchers will utilize a combination of statistical biophysics and functional diversity approaches to enhance the accuracy of disease classifiers. Patients may benefit from more precise and personalized diagnostic tools based on their immune repertoire.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune diseases, cancers, or those undergoing treatment for infections.
Not a fit: Patients with stable, non-autoimmune conditions or those not requiring diagnostic evaluation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and personalized diagnostic methods for a range of diseases.
How similar studies have performed: Preliminary studies have shown promising results with similar approaches, achieving high accuracy in identifying vaccination status and other health conditions.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ARNAOUT, RAMY — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: ARNAOUT, RAMY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autoimmune disorder, autoimmunity disease, Autoimmune Diseases