Developing tools to detect genetic variations in immune system genes
Computational toolkit for robust detection of genomic variation in human leukocyte antigen genes
This study is working on better tools to find genetic changes in HLA genes that are connected to many diseases, so that doctors can more accurately diagnose and tailor treatments for patients based on their unique genetic information.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11057574 on NIH RePORTER |
What this research studies
This research focuses on creating advanced computational tools to accurately identify genetic variations in human leukocyte antigen (HLA) genes, which are linked to over 200 diseases. The project aims to enhance existing tools for detecting these variations by improving their accuracy and scalability, making them more reliable for clinical use. By integrating and refining previously developed tools, the research will establish a robust pipeline for analyzing genetic data from large-scale genomic sequencing projects. Patients may benefit from improved diagnostic capabilities and personalized treatment options based on their genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune diseases or those undergoing genetic testing related to HLA genes.
Not a fit: Patients without any genetic predisposition to autoimmune diseases or those not involved in genetic testing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and tailored treatments for patients with autoimmune diseases and other conditions linked to HLA gene variations.
How similar studies have performed: Other research has shown success in developing computational tools for genetic analysis, indicating a promising potential for this novel approach.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Shukla, Sachet Ashok — University of Tx Md Anderson Can Ctr
- Study coordinator: Shukla, Sachet Ashok
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.