Developing tools to analyze how genes work together in real-time
Official title: An integrated toolkit for real-time analysis of coupled nascent transcription
Funded at Massachusetts Institute of Technology · NIH-11093319 · Data updated 2026-11-12
This study is looking at how two specific genes work together in real-time inside living cells, which could help us better understand how genes control important functions in our bodies and how this knowledge might help prevent diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | June 1, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $381,084 |
| NIH project number | 5R01EB035127-02 |
| Project ID | NIH-11093319 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders linked to dysregulated gene expression.
✕Less likely to help
Patients with conditions unrelated to gene expression or those not affected by genetic disorders may not benefit from this research.
What this research studies
This research focuses on understanding how two genes can be expressed together and how this expression can be measured in real-time. By creating a new toolkit that combines experimental techniques and computational modeling, the researchers aim to visualize the transcription of these genes as it happens in living cells. This approach will help clarify whether the expression of these genes is working together, against each other, or independently. The ultimate goal is to improve our understanding of gene regulation, which is crucial for cellular function and disease prevention.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation that may improve treatments for diseases caused by gene expression dysregulation.
How similar studies have gone: While the specific approach of real-time analysis of coupled nascent transcription is novel, similar methodologies have shown promise in understanding gene expression dynamics.
Where this research is happening
-
Massachusetts Institute of Technology
Cambridge, United States Active
Researchers
- Principal investigator: Hansen, Anders Sejr — Massachusetts Institute of Technology
- Study coordinator: Hansen, Anders Sejr
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.