Developing tools for analyzing genetic data from eukaryotic pathogens
Official title: Data and analysis ecosystem for eukaryotic pathogen targeted sequencing
Funded at University of California, San Francisco · NIH-11123462 · Data updated 2026-11-12
This study is working on new software to help scientists better understand the genetic information of certain germs that can make people sick, like viruses and parasites, so that we can improve treatments and learn how these germs spread and resist medicines.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | June 21, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $957,169 |
| NIH project number | 4U01AI184646-02 |
| Project ID | NIH-11123462 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include individuals affected by infections from eukaryotic pathogens, such as those with AIDS or Chagas disease.
✕Less likely to help
Patients with bacterial or viral infections that do not involve eukaryotic pathogens may not receive direct benefits from this research.
What this research studies
This research focuses on creating advanced software and computational tools to analyze genomic data from eukaryotic pathogens, which include complex organisms like certain viruses and parasites. By addressing the unique challenges posed by these pathogens, such as their larger genomes and complicated transmission dynamics, the project aims to improve the accuracy and reproducibility of genomic analyses. Patients may benefit from enhanced understanding of pathogen evolution, transmission patterns, and drug resistance, ultimately leading to better treatment strategies. The research will involve developing bioinformatics pipelines and data standards to facilitate the sharing and analysis of genomic data.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and treatment options for infections caused by eukaryotic pathogens.
How similar studies have gone: Other research has shown success in developing genomic analysis tools for simpler organisms, but this approach for eukaryotic pathogens is relatively novel.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Greenhouse, Bryan R — University of California, San Francisco
- Study coordinator: Greenhouse, Bryan R
Related research
Other NIH-funded projects on the same topics.
-
How cancer cells use exosomes to evade the immune system
This study is looking at how cancer cells use tiny bubbles called exosomes to hide proteins that can keep your immune system from fighting the tumor, and by figuring this out, the researchers hope to help doctors understand why some people respond well to cancer treatments while others don’t, ultimately aiming to creat
-
Reducing harm from smoking using electronic cigarettes
This study is looking at whether using electronic cigarettes can be a safer option for people who smoke traditional cigarettes, by comparing the health effects and exposure to harmful substances between the two.
-
Understanding how knee pain and knee obesity and muscle loss affect knee osteoarthritis
This project looks at how knee swelling, excess knee fat, and muscle loss relate to pain and structural changes in knee osteoarthritis in adults.
-
Cutaneous opioid signals in skin inflammation
A mentor-identified clinician-researcher at UCSF is studying how natural skin opioids regulate itch and pain in inflammatory skin conditions like eczema and hidradenitis, with plans to map where these opioids come from and how they affect skin nerves.
-
Pooling international data to understand long-term bisphosphonate use and atypical femur fractures
This project combines large patient datasets from multiple countries to understand how long-term bisphosphonate use relates to rare hip and thigh bone fractures, helping doctors and patients make safer treatment choices.
-
Airway cell and immune cell talks in lung transplant failure
This grant tests how airway cells and immune cells interact to drive chronic rejection after lung transplant, with the goal of slowing or preventing scar-like damage.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.