Developing small molecules to inhibit a protein linked to aging
Targeting the longevity regulator PAPP-A with small molecule inhibitors
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11100110
This study is looking at new tiny drugs that could help slow down aging and lower the risk of diseases like cancer and heart problems by blocking a specific protein called PAPP-A, and it's for anyone interested in ways to live a healthier, longer life.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11100110 on ClinicalTrials.gov |
What this research studies
This research focuses on creating small molecule inhibitors that target the PAPP-A protease, which plays a role in aging and age-related diseases. By inhibiting PAPP-A, the study aims to modulate IGF1 signaling, potentially slowing down aging and reducing the risk of conditions like cancer and cardiovascular disease. The approach involves designing and testing these inhibitors in laboratory settings to assess their effectiveness and safety. If successful, this could lead to new treatments that help extend healthy lifespan.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are interested in interventions related to aging and age-related pathologies.
Not a fit: Patients with acute conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic options to slow aging and prevent age-related diseases.
How similar studies have performed: While there have been successful studies using antibodies against PAPP-A, the development of small molecule inhibitors is a novel approach in this field.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NIKOLOVSKA-COLESKA, ZANETA — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: NIKOLOVSKA-COLESKA, ZANETA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease