Developing silicone materials that release nitric oxide to prevent blood clots and infections
Official title: Long-term and Mediated NO-Release Silicone Polymers for Blood Interface Devices
Funded at Bowling Green State University · NIH-10654071 · Data updated 2026-11-12
This study is looking at new materials that can help keep patients safe from blood clots and infections while using long-term medical devices, like catheters, by slowly releasing a helpful gas called nitric oxide, which works like the natural lining of blood vessels.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Bowling Green State University NIH-funded |
| Lab location | 1 site (Bowling Green, United States) |
| Project start | May 3, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $434,357 |
| NIH project number | 1R15HL168693-01 |
| Project ID | NIH-10654071 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who require long-term hospitalization and the use of blood interface devices.
✕Less likely to help
Patients who do not require long-term medical devices or who are not hospitalized for extended periods may not benefit from this research.
What this research studies
This research focuses on creating new silicone polymers that can release nitric oxide (NO) to help prevent blood clots and infections in patients who require long-term medical devices. The approach involves designing polymeric materials that mimic the natural lining of blood vessels, which can inhibit platelet activation and reduce the risk of microbial infections. By using advanced materials that provide a sustained release of NO, the research aims to improve the safety and effectiveness of blood interface devices used in hospitals. Patients with long-term stays in medical facilities may benefit from these innovations, as they could lead to better health outcomes.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of blood clots and infections for patients using long-term medical devices.
How similar studies have gone: Previous research has shown promise in using nitric oxide-releasing materials for medical applications, indicating potential for success in this novel approach.
Where this research is happening
-
Bowling Green State University
Bowling Green, United States Active
Researchers
- Principal investigator: Furgal, Joseph — Bowling Green State University
- Study coordinator: Furgal, Joseph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.