Developing peptides to combat antibiotic resistance
Plugging & Pulling-in: tuning peptides for ToIC to overcome anitbiotic resistance
This study is looking at new ways to help antibiotics work better against stubborn infections by using special proteins to block or use the bacteria's own pumps that push antibiotics out, making it easier for the medicine to do its job.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Lawrence NIH-funded |
| Lab location | 1 site (Lawrence, United States) |
| Project ID | NIH-10894274 on NIH RePORTER |
What this research studies
This research focuses on overcoming antibiotic resistance, which is a significant health threat. It investigates how specific peptides can interact with bacterial efflux pumps, which are responsible for expelling antibiotics from bacterial cells, thereby reducing their effectiveness. By targeting the outer membrane barrel of these pumps, the research aims to either plug them to prevent antibiotic efflux or use them to deliver drugs that cannot normally penetrate bacterial membranes. The ultimate goal is to enhance the efficacy of existing antibiotics and develop new treatment strategies for resistant infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from antibiotic-resistant infections.
Not a fit: Patients with infections that are not caused by antibiotic-resistant bacteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that restore the effectiveness of existing antibiotics against resistant bacterial infections.
How similar studies have performed: Previous research has shown promise in targeting efflux pumps to combat antibiotic resistance, indicating that this approach has potential for success.
Where this research is happening
Lawrence, United States
- University of Kansas Lawrence — Lawrence, United States (Active)
Researchers
- Principal investigator: Slusky, Joanna Sg — University of Kansas Lawrence
- Study coordinator: Slusky, Joanna Sg
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.