Developing new treatments for asthma
Official title: The Next Wave of Asthma Therapeutics
Funded at Biotherapeutics, INC. · NIH-11063906 · Data updated 2026-11-12
This study is exploring new ways to treat asthma by using advanced technology to find better options for people who struggle with current treatments, focusing on reducing inflammation in the lungs.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Biotherapeutics, INC. NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $347,608 |
| NIH project number | 1R43HL177843-01 |
| Project ID | NIH-11063906 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with asthma, particularly those who have not responded adequately to existing therapies.
✕Less likely to help
Patients with mild asthma who are well-controlled on current therapies may not benefit from this research.
What this research studies
This research focuses on creating innovative therapies for asthma by utilizing advanced computational modeling and experimental techniques. The project aims to target a new immunoregulatory pathway that could improve treatment outcomes for patients suffering from various forms of asthma, particularly those who do not respond well to existing therapies. By addressing the underlying inflammation associated with asthma, the research seeks to provide safer and more effective options for patients. The approach involves manipulating regulatory T cells to enhance their ability to suppress inflammation.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer asthma treatments for patients who currently have limited options.
How similar studies have gone: While there have been challenges in previous attempts to develop new asthma therapies, the innovative approach of targeting regulatory T cells represents a novel direction that has not been extensively tested.
Where this research is happening
-
Biotherapeutics, INC.
Blacksburg, United States Active
Researchers
- Principal investigator: Bassaganya-Riera, Josep — Biotherapeutics, INC.
- Study coordinator: Bassaganya-Riera, Josep
Related research
Other NIH-funded projects on the same topics.
-
GLP-1 receptor agonists as immune targets to treat asthma in lean and obese adults
Aims to understand how GLP-1R‑agonist diabetes medicines may directly calm immune cells to reduce asthma in adults who are lean or obese.
-
Understanding how a type of immune cell called ILC2s affect asthma in adults
This grant studies how group 2 innate lymphoid cells influence asthma in adults to help identify new ways to manage airway inflammation.
-
Expanding understanding of asthma in kids through airways and blood profiling
A study at UC San Francisco will profile blood and nasal/sputum samples from 300 youth (including 200 with asthma) over a year to understand how environmental and social factors influence asthma in marginalized communities.
-
Preventing and improving asthma care for children in urban communities
This program will try several approaches — from giving helpful bacteria to babies to allergy immunotherapy and advanced airway testing — to prevent and better treat asthma in children who live in cities.
-
IDEAL project helps predict vaccine response, infections, and asthma in early childhood
A Child-focused program will collect and share saliva, blood, and tissue samples from diverse infants to find biological patterns that predict how vaccines work, how respiratory infections occur, and who develops asthma.
-
Understanding how early-life immune development affects vaccine responses and asthma risk in children
This project uses lab-grown human immune cells from infants and young children to explore why some kids respond poorly to vaccines and are more prone to respiratory infections and asthma.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.