Developing new methods to modify organic compounds for better disease treatment
Official title: Catalyst- and Reagent-Guided Selective Alkyl C-H Bond Functionalization
Funded at University of California Berkeley · NIH-11009066 · Data updated 2026-11-12
This study is working on a smarter way to create new medicines for diseases by making it easier and faster to change certain parts of chemical compounds, which could help find effective treatments more quickly.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | February 15, 2023 |
| Project end | February 14, 2026 |
| Funding year | 2025 |
| Award (this year) | $76,756 |
| NIH project number | 5F32GM146425-03 |
| Project ID | NIH-11009066 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that currently lack effective treatments or require new therapeutic options.
✕Less likely to help
Patients with well-established treatments for their conditions may not benefit directly from this research.
What this research studies
This research focuses on improving the process of creating new clinical candidates for treating human diseases by enhancing synthetic technologies. It aims to maximize the variety of organic compounds that can be produced from a single precursor, which could significantly reduce the time needed to identify effective treatments. The approach involves late-stage functionalization of carbon-hydrogen bonds using transition-metal catalysts, allowing for the introduction of various functional groups into lead structures. By achieving better control over the selectivity of these modifications, the research seeks to streamline the development of new medications.
Why it matters
Potential benefit: If successful, this research could lead to faster identification of effective treatments for various human diseases.
How similar studies have gone: Previous research has shown promise in using similar synthetic approaches to enhance drug development, indicating potential for success in this area.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: D'angelo, Kyan Anthony — University of California Berkeley
- Study coordinator: D'angelo, Kyan Anthony
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.