Developing new methods to create medicines from natural compounds
Official title: New Methods for the Synthesis of Biologically Active Compounds
Funded at New York University · NIH-11053347 · Data updated 2026-11-12
This study is all about finding new ways to create medicines that could help fight diseases like cancer, malaria, and bacterial infections by exploring a special type of natural compound, and it’s for anyone interested in how new treatments are developed.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $402,500 |
| NIH project number | 5R35GM148203-03 |
| Project ID | NIH-11053347 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with cancer, malaria, or bacterial infections who may benefit from novel therapeutic agents.
✕Less likely to help
Patients with conditions unrelated to cancer, malaria, or bacterial infections may not receive any benefit from this research.
What this research studies
This research focuses on creating new chemical reactions to synthesize compounds that could be used as medicines, particularly targeting diseases like cancer, malaria, and bacterial infections. The team will explore cyclic peroxides, a type of natural product known for their diverse biological activities, and investigate how they can induce cell death through a process called ferroptosis. By optimizing the potency and stability of a specific cyclic peroxide, FINO2, the researchers aim to uncover its mechanisms and improve its effectiveness as a treatment. Additionally, they will work on synthesizing other related compounds and studying important chemical reactions that contribute to drug development.
Why it matters
Potential benefit: If successful, this research could lead to the development of new and effective treatments for cancer and other serious diseases.
How similar studies have gone: Other research has shown promise in using cyclic peroxides for therapeutic applications, indicating a potential for success in this approach.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Woerpel, Keith Allen — New York University
- Study coordinator: Woerpel, Keith Allen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.