Developing new methods to create complex molecules for potential drug development
Official title: Studies in the Synthesis of Complex Organic Molecules with Donor-Donor Carbenes
Funded at University of California at Davis · NIH-10913977 · Data updated 2026-11-12
This study is all about finding new ways to quickly make complex molecules that could help create new medicines, using a special type of chemical called rhodium donor-donor carbenes to discover new reactions that could lead to important compounds for drug development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $380,265 |
| NIH project number | 5R35GM149209-02 |
| Project ID | NIH-10913977 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals suffering from acute or chronic diseases that currently lack effective treatment options.
✕Less likely to help
Patients with conditions that are already well-managed by existing treatments may not see direct benefits from this research.
What this research studies
This research focuses on creating innovative synthetic methods to rapidly prepare complex organic molecules that could lead to new drugs. By exploring the reactivity of rhodium donor-donor carbenes, the project aims to unlock new chemical reactions that can produce useful compounds. The researchers will investigate how these carbenes can be utilized in various applications, particularly in forming reactive dienes for drug discovery. This work is crucial for addressing the current limitations in accessing complex molecular structures that are not widely patented.
Why it matters
Potential benefit: If successful, this research could lead to the development of new drugs that are more effective in treating both acute and chronic diseases.
How similar studies have gone: Previous research has shown promise in developing new synthetic methods for drug discovery, indicating that this approach could yield significant advancements.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Shaw, Jared Thomas — University of California at Davis
- Study coordinator: Shaw, Jared Thomas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.