Developing new inhibitors for important enzymes related to various diseases
Metal-binding Isosteres for Influenza Endonuclease Inhibitors and Beyond
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10808101
This study is working on developing new medicines that can help treat diseases like cancer and infections by targeting special proteins in our bodies that rely on metal ions, with the goal of finding better treatment options for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10808101 on ClinicalTrials.gov |
What this research studies
This research focuses on creating new inhibitors for metalloenzymes, which are crucial for many biological processes and play a role in diseases like cancer and bacterial infections. The approach combines bioinorganic chemistry with medicinal chemistry to design small molecules that can effectively bind to the metal ions in these enzymes. By improving the properties of these molecules through isostere replacement, the research aims to discover more effective treatments for conditions linked to metalloenzymes. Patients may benefit from new therapeutic options that target these critical enzymes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from diseases related to metalloenzyme activity, including certain cancers and bacterial infections.
Not a fit: Patients with conditions not associated with metalloenzymes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for diseases such as cancer and bacterial infections.
How similar studies have performed: Previous research has shown promise in developing metalloenzyme inhibitors, indicating that this approach has potential for success.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COHEN, SETH M — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: COHEN, SETH M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacteria infection, bacterial disease, Bacterial Infections, Cancers, neoplasm/cancer