Developing antibodies to target specific protein splice variants
DIRECTED DISCOVERY AND VALIDATION OF ANTI-SPLICE-JUNCTION SITE Abs
This study is working on a new way to find and test special antibodies that can help us understand and treat diseases like cancer by focusing on how proteins are made in different forms, which can change how they behave in the body.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Abbratech, INC. NIH-funded |
| Lab location | 1 site (Branford, UNITED STATES) |
| Project ID | NIH-11013261 on NIH RePORTER |
What this research studies
This research aims to create a platform for identifying and validating antibodies that specifically target splice-junction sites of protein isoforms. By utilizing innovative phage display technology, the project will validate existing antibodies and generate new ones to address the challenges posed by alternative splicing, which is crucial for understanding diseases like cancer. The research will involve techniques such as western blotting and flow cytometry to ensure the effectiveness of these antibodies. Ultimately, this work could lead to better diagnostic and therapeutic options for patients affected by conditions related to alternative splicing.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers or other diseases where alternative splicing plays a significant role.
Not a fit: Patients with conditions unrelated to alternative splicing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for patients with diseases linked to alternative splicing.
How similar studies have performed: Other research has shown promise in targeting splice variants with antibodies, indicating potential success for this novel approach.
Where this research is happening
Branford, UNITED STATES
- Abbratech, INC. — Branford, United States (Active)
Researchers
- Principal investigator: Weiner, Michael P — Abbratech, INC.
- Study coordinator: Weiner, Michael P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.