Creating special antibodies to find disease-related protein changes
DIRECTED DISCOVERY AND VALIDATION OF ANTI-SPLICE-JUNCTION SITE Abs
This project aims to create new tools, called antibodies, that can find specific changes in proteins linked to various diseases, including cancer.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Abbratech, INC. NIH-funded |
| Lab location | 1 site (Branford, UNITED STATES) |
| Project ID | NIH-11196584 on NIH RePORTER |
What this research studies
Many diseases, especially cancer, are linked to tiny changes in how our bodies make proteins, a process called alternative splicing. These changes can create unique protein forms that are hard to detect. This project is developing an innovative technology to create highly specific antibodies that can pinpoint these unique protein forms. By finding these specific protein changes, we hope to better understand diseases and develop new ways to treat them. The initial work will confirm existing antibodies and then use a new method to create even more precise ones, with a special focus on cancer-related proteins.
Who could benefit from this research
Good fit: Patients with diseases where alternative splicing plays a role, particularly certain types of cancer, could eventually benefit from the insights and tools developed through this research.
Not a fit: Patients whose conditions are not related to alternative splicing or specific protein isoform changes would likely not directly benefit from this particular research.
Why it matters
Potential benefit: If successful, this work could lead to better ways to identify disease-specific protein changes, potentially improving diagnosis and guiding the development of new treatments for conditions like cancer.
How similar studies have performed: This project introduces an innovative 'Epivolve' phage display technology, suggesting a novel approach to generating site-directed antibodies against splice variants.
Where this research is happening
Branford, UNITED STATES
- Abbratech, INC. — Branford, United States (Active)
Researchers
- Principal investigator: Li, Xiaofeng — Abbratech, INC.
- Study coordinator: Li, Xiaofeng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.