Developing advanced tools for imaging in small animals
Official title: Next-Generation ATP-Independent Luciferases, Luciferins, and Bioluminescent Calcium Indicators
Funded at University of Virginia · NIH-11023069 · Data updated 2026-11-12
This study is working on new glowing tools that help scientists see inside small animals without needing special energy, making it easier to understand diseases and how the body works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | February 5, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $461,296 |
| NIH project number | 5R01EB035430-02 |
| Project ID | NIH-11023069 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include researchers and scientists working with animal models in biomedical studies.
✕Less likely to help
Patients who are not involved in animal research or do not have a direct interest in bioluminescent imaging technologies may not benefit from this research.
What this research studies
This research focuses on creating next-generation bioluminescent tools that do not require ATP for their function, which will enhance imaging capabilities in small animal models. The team aims to address current limitations of existing luciferases and luciferins, such as poor tissue penetration and stability. By developing new luciferin compounds and bioluminescent calcium indicators, the project seeks to improve the quality and effectiveness of imaging studies, which are crucial for understanding biological processes and disease mechanisms. This work will ultimately provide researchers with better tools for studying various conditions in live animals.
Why it matters
Potential benefit: If successful, this research could lead to improved imaging techniques that enhance our understanding of diseases and biological processes in small animals.
How similar studies have gone: Previous research has shown promise in developing bioluminescent imaging tools, but this project aims to address specific limitations that have not yet been fully resolved.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Ai, Huiwang — University of Virginia
- Study coordinator: Ai, Huiwang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.