Developing advanced fluorescent nanoparticles for improved cell analysis
Official title: An expanded 75-color panel of Pdots for spectral multiplexing
Funded at Lamprogen, INC. · NIH-10897281 · Data updated 2026-11-12
This study is working on a new type of tiny particles that can help doctors see and understand different types of cells in your body better, which could lead to more accurate tests and treatments for autoimmune diseases and cancers.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lamprogen, INC. NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $499,583 |
| NIH project number | 5R44GM151936-02 |
| Project ID | NIH-10897281 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with autoimmune diseases or cancers who may benefit from improved diagnostic techniques.
✕Less likely to help
Patients who do not have autoimmune diseases or cancers may not receive direct benefits from this research.
What this research studies
This research focuses on enhancing flow cytometry techniques by creating a new family of ultrabright fluorescent nanoparticles, known as Pdots. These nanoparticles will allow for better detection and analysis of various cell types, including B cells and T cells, by providing clearer spectral signatures. The approach aims to simplify the process of identifying overlapping signals from different fluorescent markers, which can improve the resolution of cell subpopulations in clinical diagnostics and research. Patients may benefit from more accurate diagnostic tools and treatments for autoimmune diseases and cancers as a result of this work.
Why it matters
Potential benefit: If successful, this research could lead to more precise diagnostic tools and therapies for patients with autoimmune diseases and cancers.
How similar studies have gone: Other research has shown success with similar approaches in enhancing flow cytometry techniques, making this a promising area of investigation.
Where this research is happening
-
Lamprogen, INC.
Seattle, United States Active
Researchers
- Principal investigator: Yu, Jiangbo — Lamprogen, INC.
- Study coordinator: Yu, Jiangbo
Related research
Other NIH-funded projects on the same topics.
-
Deep profiling of tiny cells in tissue with ultra-bright dyes
A new imaging method aims to map many protein markers in tissue sections at once, helping doctors understand cancers and heart diseases better.
-
Improving cancer detection using advanced PCR techniques
This study is working on a new way to improve a test that checks for multiple genetic markers at the same time, making it easier and quicker to diagnose cancer early, so patients can get the help they need faster.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.