Deep profiling of tiny cells in tissue with ultra-bright dyes
Official title: Deep Immunophenotyping in tissue imaging
Funded at Lamprogen, INC. · NIH-11381043 · Data updated 2026-11-12
A new imaging method aims to map many protein markers in tissue sections at once, helping doctors understand cancers and heart diseases better.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lamprogen, INC. NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 1, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $850,740 |
| NIH project number | 5R44GM161324-02 |
| Project ID | NIH-11381043 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals whose tumors or heart tissue samples could be analyzed with advanced imaging to tailor therapies.
✕Less likely to help
Patients without access to tissue samples or those not undergoing tissue-based diagnostics may not directly benefit.
What this research studies
This project develops ultra-bright fluorescent particles to dramatically increase the number of markers that can be seen in tissue images, speeding up how researchers and clinicians study immune cells and disease biology. It focuses on making imaging cheaper, faster, and easier so pathology labs can use it more routinely. By achieving very high multiplexing, the work could improve how we profile tissue samples from patients for better diagnosis and precision medicine.
Why it matters
Potential benefit: If successful, patients could benefit from more accurate tissue profiling that informs diagnosis and personalized treatment decisions.
How similar studies have gone: Similar high-mplexity imaging approaches have shown promise in research settings, with advancing methods gradually moving toward clinical use.
Where this research is happening
-
Lamprogen, INC.
Seattle, United States Active
Researchers
- Principal investigator: Yu, Jiangbo — Lamprogen, INC.
- Study coordinator: Yu, Jiangbo
Related research
Other NIH-funded projects on the same topics.
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Developing advanced fluorescent nanoparticles for improved cell analysis
This study is working on a new type of tiny particles that can help doctors see and understand different types of cells in your body better, which could lead to more accurate tests and treatments for autoimmune diseases and cancers.
-
Improving cancer detection using advanced PCR techniques
This study is working on a new way to improve a test that checks for multiple genetic markers at the same time, making it easier and quicker to diagnose cancer early, so patients can get the help they need faster.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.