Developing a system to label RNAs at specific sites
Official title: MFB: Fluidics system for efficient site-specific labeling of RNAs
Funded at University of Massachusetts Amherst · NIH-11124216 · Data updated 2026-11-12
This study is exploring a new way to add special changes to RNA, which could help us better understand how RNA works in our bodies and how it can be used to create new treatments for diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Massachusetts Amherst NIH-funded |
| Lab location | 1 site (Hadley, United States) |
| Project start | July 1, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $421,618 |
| NIH project number | 5R01HG013861-02 |
| Project ID | NIH-11124216 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to RNA dysfunction or those who may benefit from RNA-based therapies.
✕Less likely to help
Patients with conditions unrelated to RNA biology or those not requiring RNA-based interventions may not receive benefits from this research.
What this research studies
This research focuses on creating a new enzymatic system that allows for the incorporation of multiple modified bases into RNA at specific positions. By building on recent advances in flow transcription, the project aims to enhance our understanding of RNA translation and alternative splicing, which are crucial for various biological processes. The methodology involves synthesizing RNA with precise modifications, enabling detailed studies of RNA structure and dynamics using advanced techniques like FRET and NMR. This could lead to significant insights into how RNA modifications affect cellular functions and inform the development of RNA-based therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved RNA therapeutics by providing a deeper understanding of RNA modifications and their roles in cellular processes.
How similar studies have gone: Other research has shown promise in using site-specific RNA modifications to enhance our understanding of RNA biology, indicating that this approach has potential for success.
Where this research is happening
-
University of Massachusetts Amherst
Hadley, United States Active
Researchers
- Principal investigator: Martin, Craig T — University of Massachusetts Amherst
- Study coordinator: Martin, Craig T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.