Developing a system for precise light delivery in cancer treatment
In situ PEDSy and light delivery platform for Intracavitory Photodynamic Therapy
This study is working on a new system to make photodynamic therapy (PDT) better for patients with lung-related cancers, like mesothelioma, by using special technology to measure and deliver the right amount of treatment while keeping an eye on how the light spreads in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10674694 on NIH RePORTER |
What this research studies
This project aims to create an advanced system for photodynamic therapy (PDT) that accurately measures and delivers treatment doses in real-time. It involves innovative hardware and software components that monitor light distribution in the pleural cavity during PDT for patients with pleural malignancies, such as mesothelioma. The system will utilize fiber-optic technology to assess tissue properties and ensure effective drug concentration during treatment. By integrating these technologies, the research seeks to enhance the efficacy of PDT and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pleural malignancies, particularly mesothelioma, who are eligible for photodynamic therapy.
Not a fit: Patients with non-pleural cancers or those not eligible for photodynamic therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer treatments for patients undergoing photodynamic therapy.
How similar studies have performed: Previous clinical trials have shown significant efficacy of photodynamic therapy in treating mesothelioma, indicating that this approach has a foundation of success.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Zhu, Timothy C. — University of Pennsylvania
- Study coordinator: Zhu, Timothy C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.