Developing a one-time gene therapy to suppress HIV replication.
Non-viral gene therapy with eCD4-Ig
This study is testing a new type of gene therapy that uses a special protein to help keep HIV under control with just one shot in the muscle, so people living with HIV might not need to take daily medications anymore.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emmune, INC NIH-funded |
| Lab location | 1 site (Juno Beach, UNITED STATES) |
| Project ID | NIH-11195805 on NIH RePORTER |
What this research studies
This research focuses on creating a non-viral gene therapy using a therapeutic protein called eCD4-Ig, which aims to provide long-lasting suppression of HIV after a single intramuscular injection. The therapy is designed to counteract the virus's ability to escape neutralizing antibodies, which is a significant challenge in treating HIV. By enhancing the efficiency of gene transfer into skeletal muscle, the researchers hope to maintain effective levels of eCD4-Ig in the body for a lifetime. This innovative approach could potentially eliminate the need for ongoing treatments for HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are seeking a more permanent treatment option.
Not a fit: Patients who are not infected with HIV or those who have advanced AIDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a long-term solution for managing HIV, significantly improving the quality of life for patients.
How similar studies have performed: While gene therapy for HIV is an emerging field, this specific approach using eCD4-Ig is novel and has not been extensively tested in clinical settings.
Where this research is happening
Juno Beach, UNITED STATES
- Emmune, INC — Juno Beach, United States (Active)
Researchers
- Principal investigator: Quinlan, Brian D — Emmune, INC
- Study coordinator: Quinlan, Brian D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.