Developing a new way to manage lower respiratory infections in resource-limited areas
A randomized controlled trial of a novel, evidence-based algorithm for managing lower respiratory tract infection in a resource-limited setting
This study is looking for a better and cheaper way to diagnose and treat lower respiratory infections, like pneumonia, in places where healthcare resources are limited, so that doctors can give the right treatment without overusing antibiotics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10894202 on NIH RePORTER |
What this research studies
This research focuses on creating a cost-effective diagnostic and treatment algorithm for lower respiratory tract infections (LRTI) in low- and middle-income countries. It aims to reduce the overprescription of antibiotics by integrating clinical predictors and point-of-care tests that can be used without extensive laboratory facilities. By utilizing an existing biorepository of patients with LRTI, the study will evaluate the effectiveness and acceptability of this new approach among healthcare providers. The goal is to improve patient outcomes by ensuring appropriate treatment based on accurate diagnoses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals of all ages experiencing symptoms of lower respiratory tract infections in low- or middle-income countries.
Not a fit: Patients who do not have lower respiratory tract infections or those in high-income countries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and better management of lower respiratory infections, reducing unnecessary antibiotic use and improving patient care.
How similar studies have performed: Other research has shown success in using point-of-care diagnostics to improve treatment outcomes in similar settings, indicating that this approach has potential.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Tillekeratne, Gayani — Duke University
- Study coordinator: Tillekeratne, Gayani
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.