Developing a new vaccine for tuberculosis using nanoparticles
Vaccinating at Mucosal Surfaces with Nanoparticle-conjugated Antigen and Adjuvant
This study is working on a new type of tuberculosis vaccine that could help adults build stronger and longer-lasting protection against the disease, especially as drug-resistant strains become more common.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11109613 on NIH RePORTER |
What this research studies
This research focuses on creating a more effective vaccine for tuberculosis (TB) that can provide long-lasting immunity, particularly for adults. It aims to identify specific immune responses, particularly from CD8+ T cells, that can be stimulated through a novel intranasal delivery method. By using nanoparticle-conjugated antigens and adjuvants, the research seeks to enhance the body's ability to fight TB, especially in light of rising drug-resistant strains. The approach involves pre-clinical studies to test these new vaccine strategies before they are potentially used in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults, particularly veterans, who are at higher risk for tuberculosis and may benefit from improved vaccination strategies.
Not a fit: Patients who are not adults or those who are not at risk for tuberculosis may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more effective TB vaccine that significantly reduces the incidence of the disease and improves the quality of life for those at risk.
How similar studies have performed: Other research has shown promise in developing vaccines using similar nanoparticle approaches, indicating potential for success in this area.
Where this research is happening
Nashville, United States
- Veterans Health Administration — Nashville, United States (Active)
Researchers
- Principal investigator: Joyce, Sebastian — Veterans Health Administration
- Study coordinator: Joyce, Sebastian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.