Developing a new vaccine for tuberculosis using nanoparticles
Official title: Vaccinating at Mucosal Surfaces with Nanoparticle-conjugated Antigen and Adjuvant
Funded at Veterans Health Administration · NIH-11109613 · Data updated 2026-11-12
This study is working on a new type of tuberculosis vaccine that could help adults build stronger and longer-lasting protection against the disease, especially as drug-resistant strains become more common.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01BX006010-03 |
| Project ID | NIH-11109613 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults, particularly veterans, who are at higher risk for tuberculosis and may benefit from improved vaccination strategies.
✕Less likely to help
Patients who are not adults or those who are not at risk for tuberculosis may not receive any benefit from this research.
What this research studies
This research focuses on creating a more effective vaccine for tuberculosis (TB) that can provide long-lasting immunity, particularly for adults. It aims to identify specific immune responses, particularly from CD8+ T cells, that can be stimulated through a novel intranasal delivery method. By using nanoparticle-conjugated antigens and adjuvants, the research seeks to enhance the body's ability to fight TB, especially in light of rising drug-resistant strains. The approach involves pre-clinical studies to test these new vaccine strategies before they are potentially used in humans.
Why it matters
Potential benefit: If successful, this research could lead to a more effective TB vaccine that significantly reduces the incidence of the disease and improves the quality of life for those at risk.
How similar studies have gone: Other research has shown promise in developing vaccines using similar nanoparticle approaches, indicating potential for success in this area.
Where this research is happening
-
Veterans Health Administration
Nashville, United States Active
Researchers
- Principal investigator: Joyce, Sebastian — Veterans Health Administration
- Study coordinator: Joyce, Sebastian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.