Developing a new therapy to treat heart failure without implants
Official title: Advancing Commercial Readiness of a No-implant Interatrial Shunt Therapy to Treat Heart Failure
Funded at Alleviant Medical, INC. · NIH-10920111 · Data updated 2026-11-12
This study is testing a new heart treatment that creates a small connection between two parts of the heart to help relieve symptoms for people with congestive heart failure, especially those who haven't found relief with other options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Alleviant Medical, INC. NIH-funded |
| Lab location | 1 site (Austin, UNITED STATES) |
| Project start | September 17, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $499,103 |
| NIH project number | 1SB1HL174252-01 |
| Project ID | NIH-10920111 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with heart failure, particularly those with preserved or mid-range ejection fraction.
✕Less likely to help
Patients with heart failure who have reduced ejection fraction or those who do not meet the specific criteria for the interatrial shunt therapy may not benefit from this research.
What this research studies
This research focuses on a novel approach to treating congestive heart failure (CHF) by using a no-implant interatrial shunt therapy. The therapy aims to create a connection between the left and right atrium of the heart, which could help lower elevated pressures in the left atrium, potentially alleviating symptoms of heart failure. The research will evaluate the safety and effectiveness of this therapy in patients with heart failure, particularly those with preserved or mid-range ejection fraction. By exploring this innovative treatment, the research seeks to provide new options for patients who currently have limited choices.
Why it matters
Potential benefit: If successful, this research could offer a new, non-invasive treatment option for patients suffering from heart failure, improving their quality of life and reducing hospitalizations.
How similar studies have gone: Previous studies on interatrial shunting have shown promising safety and efficacy results, indicating potential for success in this novel approach.
Where this research is happening
-
Alleviant Medical, INC.
Austin, United States Active
Researchers
- Principal investigator: Pate, Thomas Diffley — Alleviant Medical, INC.
- Study coordinator: Pate, Thomas Diffley
Related research
Other NIH-funded projects on the same topics.
-
AI-supported heart failure diagnosis and management in Rwanda
Aiming to help people with suspected heart failure in Rwanda get faster, more accurate diagnoses and better care using AI-guided ultrasound and care protocols.
-
AI-assisted heart failure diagnosis in Rwanda using focused ultrasound
An NIH-funded project will test whether AI-enhanced, easy-to-use heart ultrasound can help non-experts diagnose and manage heart failure in Rwanda.
-
HF endotypes in heart failure using ethical multi-modal AI and molecular data
A patient-friendly project that uses advanced AI and multiple kinds of health data to identify distinct heart failure subtypes that could guide personalized care.
-
Triple gene therapy approach to heal the heart after a heart attack
A new therapy combines three genetic approaches delivered by a virus to help the heart heal after a heart attack.
-
Digital-first heart failure care delivery in Uganda
A targeted program in Uganda tests a digital care plan to help people with heart failure manage their symptoms at home.
-
Digital-first heart failure care delivery in Uganda
A study to test digital self-care tools to help people with heart failure in Uganda manage symptoms and stay healthier.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.