Developing a new protein treatment to reduce kidney damage from medical devices
Bioengineering a novel therapeutic protein complex to minimize the effects of medical device induced hemolysis
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-11006271
This study is looking at how certain medical devices used during heart surgeries can harm red blood cells and affect kidney function, and it aims to find a way to reduce these harmful effects to help patients recover better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11006271 on ClinicalTrials.gov |
What this research studies
This research investigates how medical devices, particularly those using blood pumps during surgeries, can cause damage to red blood cells, leading to harmful substances entering the bloodstream. The team aims to understand the effects of hemolysis and the release of hemoglobin on kidney function and other organs. By measuring levels of these toxic substances in patients undergoing cardiac surgery, they hope to develop a therapeutic protein complex that can minimize the harmful effects of these toxins. This approach could lead to better management of patients who experience complications from medical devices.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients scheduled for cardiac surgeries that involve the use of cardiopulmonary bypass.
Not a fit: Patients who are not undergoing surgeries involving blood pumps or those with pre-existing severe kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce kidney injury and improve recovery outcomes for patients undergoing surgeries that require blood pumps.
How similar studies have performed: While the approach of using bioengineered proteins is innovative, similar strategies targeting hemolysis and its effects on organ function have shown promise in preliminary studies.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BUEHLER, PAUL WERNER — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: BUEHLER, PAUL WERNER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute kidney injury