Developing a framework to analyze spatial omics experiments
Official title: Statistical Power Analysis Framework for Multi-Sample and Cross-Platform Spatial Omics Experiments
Funded at Ohio State University · NIH-10777938 · Data updated 2026-11-12
This study is working on better ways to analyze how genes and proteins behave in tissues, which could help improve treatments for conditions like cancer and brain disorders, making it easier for doctors to understand how cells interact and how tissues are structured.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $410,079 |
| NIH project number | 1R01GM152585-01 |
| Project ID | NIH-10777938 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or degenerative neurologic disorders who may benefit from enhanced spatial omics analysis.
✕Less likely to help
Patients with conditions unrelated to cellular interactions or tissue architecture may not receive direct benefits from this research.
What this research studies
This research focuses on creating a statistical framework to improve the design and analysis of spatial omics experiments, which measure gene and protein expressions at a cellular level within tissues. By addressing the experimental design parameters, such as sequencing depth and Field-Of-View sizes, the research aims to enhance the understanding of tissue architecture and cell communications. Patients may benefit from advancements in treatments for conditions like cancer and degenerative neurologic disorders through improved data analysis methods. The research team combines expertise in statistical modeling, bioinformatics, and pulmonary science to ensure a comprehensive approach.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for diseases by improving our understanding of cellular interactions and tissue structures.
How similar studies have gone: Other research has shown success in using statistical frameworks for analyzing complex biological data, indicating potential for this approach.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Chung, Dongjun — Ohio State University
- Study coordinator: Chung, Dongjun
Related research
Other NIH-funded projects on the same topics.
-
Understanding how trinucleotide repeat expansions cause disease
A research project at Ohio State University is exploring how tiny DNA repeats become unstable and drive neurological and muscular diseases, with potential implications for future therapies.
-
Pediatric Prehospital Airway Resuscitation for Critically Ill Children
This grant tests the best way for paramedics to manage breathing tubes and other airways in seriously ill children before they reach the hospital.
-
From Social Breakups to Brain Changes in Alzheimer’s and Related Dementias
This grant explores how losing social connections may trigger brain changes and inflammation linked to Alzheimer’s disease and related dementias.
-
Understanding why patients with blood cancers start and stick with oral cancer medicines
A study to learn what helps or hinders Black patients with blood cancers in starting and continuing their prescribed oral cancer medicines.
-
How sex and hormones affect alcohol's impact on sleep in adults
This study tests how sex and hormone changes influence how alcohol disrupts sleep in healthy adults, with a focus on women aged 21-45.
-
Natural products to block IL-8 signaling and prevent Barrett's Esophagus from turning into esophageal cancer
A搜索-friendly plan to use safe natural compounds to interrupt a key inflammatory signal (IL-8) and stop Barrett’s esophagus from turning into esophageal cancer in people with GERD.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.