Developing a Broad Vaccine for Coronaviruses
Development of a pan-betacoronavirus vaccine
This project aims to create a new vaccine that protects against many different types of coronaviruses, including future variants, by understanding how our bodies build strong, lasting immunity.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11123408 on NIH RePORTER |
What this research studies
This project, called "PLUTO," is working to create a single vaccine that can protect against a wide range of coronaviruses, not just SARS-CoV-2. Researchers are carefully looking at how our immune system, specifically B cells, responds to past coronavirus infections and vaccinations. This deep understanding will help them design new vaccines that offer broad and long-lasting protection against current and future coronavirus threats. The goal is to develop a "variant-proof" vaccine that can keep us safe from many different types of coronaviruses.
Who could benefit from this research
Good fit: This foundational research does not directly recruit patients, but future vaccine trials stemming from this work would seek individuals interested in receiving a new coronavirus vaccine.
Not a fit: Patients not interested in receiving a new vaccine or those who do not meet specific health criteria for future clinical trials would not directly benefit from participation.
Why it matters
Potential benefit: If successful, this work could lead to a single vaccine that protects against many different coronaviruses, reducing the need for frequent updates and offering broader protection against future outbreaks.
How similar studies have performed: While current vaccines target specific coronavirus strains, this project explores a novel approach to achieve broad, pan-coronavirus protection.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Krammer, Florian — Icahn School of Medicine at Mount Sinai
- Study coordinator: Krammer, Florian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.