Detecting protein biomarkers for early cancer diagnosis using advanced nanopore technology
Solid-state nanopores and silicon nanomembranes for ultrasensitive protein biomarker detection
This study is testing a new, affordable way to quickly detect important proteins in blood and urine that could help spot early signs of serious health issues like cancer and brain injuries, especially in places that might not have access to advanced medical tools.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10815553 on NIH RePORTER |
What this research studies
This research focuses on developing a new diagnostic platform that uses solid-state nanopores to detect protein biomarkers in serum and urine at ultra-low concentrations. By utilizing a novel method for nanopore fabrication, the team aims to create a low-cost, electronic solution for point-of-care diagnostics, particularly in resource-limited settings. The approach involves a unique immunoassay that amplifies the signal from target proteins, making it easier to identify early signs of conditions like cancer and traumatic brain injury. The effectiveness of this new method will be compared to existing technologies to ensure its reliability and accuracy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for early-stage cancers or other serious conditions that can be detected through protein biomarkers in serum or urine.
Not a fit: Patients with conditions that do not involve detectable protein biomarkers in serum or urine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accessible and affordable diagnostic tools for early detection of serious health conditions.
How similar studies have performed: Previous research has shown promise in using nanopore technology for biomarker detection, indicating potential for success in this novel approach.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Mcgrath, James L — University of Rochester
- Study coordinator: Mcgrath, James L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.