Detecting antibodies linked to the development of Type 1 diabetes in children
Official title: Whole Protein Arrays to Detect Antimicrobial Antibodies Associated with Triggering and Progression of Islet Autoimmunity in TEDDY
Funded at Arizona State University-Tempe Campus · NIH-10975186 · Data updated 2026-11-12
This study is looking at how certain infections might play a role in the development of Type 1 diabetes in kids by checking their immune responses to different germs, hoping to find clues about what might trigger the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project start | September 5, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,449,016 |
| NIH project number | 1R01DK140781-01 |
| Project ID | NIH-10975186 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are part of the TEDDY cohort or at risk for developing Type 1 diabetes.
✕Less likely to help
Patients who are older than 11 years or those who do not have a family history of autoimmune diseases may not benefit from this research.
What this research studies
This research investigates the role of various microbial infections in the development of Type 1 diabetes (T1D) by analyzing antibody responses in children. Using advanced immunoproteomics technologies, the study aims to identify antibodies against a wide range of microbes in a large birth cohort known as the TEDDY study. By examining these antibody responses, researchers hope to uncover environmental factors that may trigger or influence the progression of islet autoimmunity and T1D. The study employs high-throughput protein arrays to enhance the sensitivity of antibody detection, providing a comprehensive understanding of the relationship between infections and T1D risk.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for Type 1 diabetes in children by identifying key environmental triggers.
How similar studies have gone: Previous research has shown promise in identifying environmental triggers for autoimmune diseases, but this approach using comprehensive antibody profiling is relatively novel.
Where this research is happening
-
Arizona State University-Tempe Campus
Tempe, United States Active
Researchers
- Principal investigator: Labaer, Joshua — Arizona State University-Tempe Campus
- Study coordinator: Labaer, Joshua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.