Defining chronic endometritis with new tissue and blood tests to improve diagnosis
Official title: Defining chronic endometritis using emerging transcriptomic and proteomic technologies to improve its diagnosis
Funded at Feinstein Institute for Medical Research · NIH-11451391 · Data updated 2026-11-12
Researchers will explore advanced tissue and blood-based methods to better diagnose chronic endometritis in people with unexplained infertility.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $460,625 |
| NIH project number | 1R21HD118372-01A1 |
| Project ID | NIH-11451391 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with unexplained infertility who may have chronic endometritis, and who are undergoing endometrial biopsy and potential antibiotic therapy, could participate.
✕Less likely to help
Some participants may not benefit if their CE is not present or if biomarker signals are inconclusive.
What this research studies
This project will use cutting-edge transcriptomic and proteomic analyses on endometrial biopsy samples from patients with chronic endometritis, comparing pre- and post-antibiotic treatment and healthy controls to identify cell type-specific changes. It will also test whether menstrual effluent can be used as a non-invasive source for diagnosing CE. By focusing on immune and non-immune cell activity in the endometrium, the study aims to establish clearer diagnostic criteria beyond current CD138+ plasma cell counts. The work involves collecting paired biopsies and ME samples from participants to map molecular signatures associated with CE and response to therapy. Results could lead to more accurate diagnoses and targeted treatments for infertile patients with CE.
Why it matters
Potential benefit: If successful, patients could receive faster, more accurate CE diagnoses and more effective, personalized treatment plans.
How similar studies have gone: Prior work supports that endometrial profiling and non-invasive samples can reflect CE-related changes, though comprehensive multi-omic profiling in CE is still emerging.
Where this research is happening
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Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Metz, Christine Noel — Feinstein Institute for Medical Research
- Study coordinator: Metz, Christine Noel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.