Decision support program for older adults with acute myeloid leukemia and caregivers
Official title: A decisional intervention for older adults with acute myeloid leukemia and their caregivers
Funded at University of Rochester · NIH-11252517 · Data updated 2026-11-12
This program offers decision tools and support to help older adults with acute myeloid leukemia and their caregivers understand treatment choices and manage distress.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $638,952 |
| NIH project number | 5R01CA288318-02 |
| Project ID | NIH-11252517 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 60 and older with a diagnosis of acute myeloid leukemia and their primary caregivers, particularly those facing immediate treatment decisions.
✕Less likely to help
Younger adults with AML, people not involved in decision-making, or those unable to participate (for example due to severe cognitive impairment or lack of a caregiver) may not benefit from this program.
What this research studies
If you join, you and your caregiver will receive a multilevel decision-support program called UR-GOAL that was co-designed with patients and caregivers. The program gives clear information about AML, treatment options, and likely outcomes, plus exercises to clarify what matters most to you. It also includes caregiver-focused support and strategies to reduce stress during rapid treatment decisions. Researchers will follow participants over time to see how the program affects decision-making, distress, and quality of life.
Why it matters
Potential benefit: It could help reduce emotional distress, improve quality of life, and support treatment decisions that match patient goals.
How similar studies have gone: Shared decision-making programs have improved decision quality and reduced distress in other cancer settings, and the team's prior pilot of UR-GOAL demonstrated feasibility though larger effectiveness studies are still needed.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Loh, Kah Poh — University of Rochester
- Study coordinator: Loh, Kah Poh
Related research
Other NIH-funded projects on the same topics.
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Helping older adults with acute myeloid leukemia and their caregivers make treatment decisions
This study is all about helping older adults with acute myeloid leukemia and their caregivers make better decisions about treatment by providing support and information that reflects their values, so they can feel less stressed and improve their quality of life.
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Targeting the protein housekeeping system in adult leukemia
Researchers are testing a new approach to treat acute myeloid leukemia by disrupting how AML cells manage their proteins, with the goal of helping patients live longer and healthier lives.
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Understanding how epigenetic helper proteins drive AML and how to target them
A scientist team is studying how accessory proteins in gene-regulating complexes affect acute myeloid leukemia and whether they can be targeted for safer, more precise therapies.
-
Targeting FLVCR1-enabled choline use in a aggressive AML subtype
A new approach aims to block how a specific leukemia subtype (CG-AML) takes up choline to feed its growth, potentially slowing or stopping the disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.